darning

Sun, 03 May 2026 00:17:34 +0000

Here, we show that mainly excitatory cortical neurons are affected by TDP-43 pathology and define the cell types that are affected the most: intratelencephalic L2-L3-LINC00507-FREM3,... Here, we characterize the cell-type specificity of TDP-43 pathology in the primary ALS/ALS-FTD motor cortex by employing a multi-modal approach that enables highly-resolved identification of cell types. Cytoplasmic TDP-43 pathology is a pathological sign of ALS/ALS-FTD and a converging disease event across different genotypes, phenotypes and CNS areas. To understand this process and target... In a groundbreaking advance set to redefine our understanding of neurodegenerative disorders, a team of researchers led by Ruf, Khlwein, and Meier has unveiled a multi-modal.